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Oct 28, 20202 min read

BONS Members ONLY ~ New Evidence in First-Line AML & Exploring Outcomes

Updated: Nov 2, 2020




BONS Members ONLY!

Click date links below to REGISTER through Boston ONS.


Indications VENCLEXTA is indicated: • For the treatment of adult patients with chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL). • In combination with azacitidine, or decitabine, or low-dose cytarabine for the treatment of newly-diagnosed acute myeloid leukemia (AML) in adults: ‒ 75 years or older, or ‒ who have comorbidities that preclude the use of intensive induction chemotherapy. Select Important Safety Information • Concomitant use of VENCLEXTA with strong CYP3A inhibitors at initiation and during ramp-up is contraindicated in patients with CLL/SLL due to the potential for increased risk of tumor lysis syndrome (TLS).

  • Tumor lysis syndrome, including fatal events and renal failure requiring dialysis, has occurred in patients with high tumor burden when treated with VENCLEXTA. Assess patients for risk and provide appropriate prophylaxis for TLS, including hydration and anti-hyperuricemics. Reduced renal function further increases the risk. Monitor blood chemistries and manage abnormalities promptly. Employ more intensive measures (IV hydration, frequent monitoring, hospitalization) as overall risk increases.

  • Concomitant use of VENCLEXTA with P-gp inhibitors or strong or moderate CYP3A inhibitors increases venetoclax exposure, which may increase the risk of TLS at initiation and during ramp-up phase, and requires VENCLEXTA dose adjustment.

  • Grade 3 or 4 neutropenia occurred in patients treated with VENCLEXTA. Monitor blood counts and for signs of infection; manage as medically appropriate.

  • In patients with AML, baseline neutrophil counts worsened in 95% to 100% of patients treated with VENCLEXTA in combination with azacitidine or decitabine or low-dose cytarabine. Neutropenia can recur with subsequent cycles.

  • Fatal and serious infections such as pneumonia and sepsis have occurred in patients with VENCLEXTA. Monitor patients for signs and symptoms of infection and treat promptly. Withhold VENCLEXTA for Grade 3 and 4 infection until resolution.

  • Do not administer live attenuated vaccines prior to, during, or after treatment until B-cell recovery occurs.

  • VENCLEXTA may cause embryo-fetal harm. Advise females of reproductive potential to use effective contraception during treatment and for at least 30 days after the last dose. BCL-2=B-cell lymphoma; 1L=first-line; R/R=relapsed/refractory; CME=continuing medical education.

AbbVie is committed to collaborating with healthcare professionals (HCPs), healthcare organizations (HCOs), and patient organizations to improve patient health across the globe. Our interactions with HCPs, HCOs, and patient organizations are guided by openness and transparency to ensure public trust and confidence. AbbVie supports disclosure of theserelationships wherever possible to demonstrate the integrity of our relationships with HCPs, HCOs, and patient organizations.

AbbVie reports payment and transfer of value data as required by federal and state transparency laws. Additional information regarding AbbVie’s HCP and HCO transparency reporting is available on the www.abbvie.com website. If you have any questions, please speak to your AbbVie contact or email TransparencyReporting@abbvie.com.

  • Please see additional Important Safety Information on back. Please see accompanying full Prescribing Information.



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